Mon, 18 Dec 2017

Apoptosis Induction of Punica Granatum Extract on Human Lung Cancer Cells

J.Sangeetha1*, K.Vijayalakshmi1

1. Department of Biochemistry, Bharathi Women’s College, North Chennai -600108, TamilNadu, India.


ABSTRACT

The present study evaluated the ability of methanolic extract of punica granatum to induce apoptosis in lung cancer cell lines.A549 cells emerged as the most sensitive cell line for in-vitro growth inhibitory activity. A total of 50-60% confluent cells were treated with Punica granatum rind extract and their fraction for 48 hrs in complete growth medium. The ethyl acetate fraction induces uppermost cell death in the A549 cells which indicate the maximum growth inhibition. Ethyl acetate fraction of punica granatum extract induces apoptosis in A549 cells as indicated by nuclear condensation and increased annexin staining. It is possible that the use of punica granatum rind extract as a component in herbal medicines could be justifiable.

Keywords: Apoptosis, lung cancer, punica granatum.

 


[PDF]  Viewed: 697  Downloaded: 106
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter