Mon, 18 Dec 2017

Preparation and Characterization of Amlodipine Besylate Polymorphs

Chandrashekar Thalluri 1*, Vijay Kumar Bontha2, Devanna N3

1. Department of Pharmaceutics, S.R. College of pharmacy, Warangal, AndhraPradesh, India.

2. Department of Pharmaceutics, Janagoan Institute of Pharmaceutical Sciences, Janagoan, Warangal,Andhra Pradesh, India.

3. Department of Chemistry, Jawaharlal Nehru Technological University, Ananthapur, Andhra Pradesh, India.


ABSTRACT

The objective of the present work was to make different crystal forms of Amlodipine besylate. It was planned to prepare crystal forms using solvents of varying polarity and by change of phase and it was extended to characterize the prepared crystal forms using techniques like Scanning electron microscopy, IR spectroscopy, and Differential scanning calorimetry and/or X-ray diffractometry. Based on above these studies Amlodipine besylate pure was exisisted as Amlo-I, Amlo-II, Amlo –III and Amlo-IV forms were different in size and shape.

Keywords: Amlodipine besylate, Scanning electron microscopy, IR spectroscopy and Differential scanning calorimetry and/or X-ray diffractometry.

 

 


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