DOI: 10.21276/ajptr
Mon, 20 May 2019

UGT1A1*28 Polymorphism Related Toxicities are more Frequent in Chemotherapy Na´ve Patients

Amany El-Zeiny1, Ahmed El Bastawisy 2, Abeer Bahnasy 3, Samar Farid 4

1. Clinical Pharmacy,National Cancer Institute, Cairo University, Cairo, Egypt.

2. Lecturer of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.

3. Professor of Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.

4. Assistant Prof. of Clinical Pharmacy,Faculty of Pharmacy, Cairo University, Cairo, Egypt.


Irinotecan( CPT-11 ) is an important chemotherapy for the treatment of colorectal cancers. The main drawback is its toxicity which includes Neutropenia and Diarrhea.  Some studies confirms the correlation between increasing the incidence of Neutropenia and Diarrhea in patients with UGT1A1*28 polymorphism and other studies could not conclude it. So, other factors may incorporate to act with the presence of the polymorphism to increase CPT-11 toxicity. In this study, we try to find these factors. Patients were divided into 2 groups according to the presence or absence of previous chemotherapy treatment. All patients received standard IFL regimen. Primary endpoint was: comparison between the 2 groups as regard to toxicities. Secondary endpoint was assessment of the incidence of UGT1A1*28 polymorphism. UGT1A1*28 polymorphism was present in 20 patients (43%) of them 15% are homozygous. Twenty three patients were chemotherapy naive in group (1) and 20 patients in group (2) had received previous chemotherapy. Grade (II-IV) neutropenia were found in 52 % of group 1 versus 20 % of group 2 (P=0.1). Grade (II-IV) diarrhea was found in 52 % of patients of group 1 and 15% of patients with group 2 (P=0.05).Treatment delay occurred in 29.16 % of group 1 versus 72.4 % of group 2. (P=0.1). The study concluded that UGT1A1*28 polymorphism is present frequently (43%) in a Caucasian population and is associated with more incidence of toxicity in chemotherapy naïve patients.

Keywords: Irinotecan, UGT1A1, Colorectal, Previous Chemotherapy.

[PDF]   Viewed: 1335   Downloaded: 80
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter