Mon, 18 Dec 2017

Efficacy of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Muscle Relaxants and Neurotropic Drugs in Patients with Low Back Pain

Patel IB1, Bairy KL1*, Bhat SN2, Shetty DJ1, Shalini A1, Esha R3

1. Department of Pharmacology, Kasturba Medical College, Manipal Univeristy, Manipal, Karnataka 576104.

2. Department of Orthopaedics, Kasturba Medical College, Manipal Univeristy, Manipal, Karnataka 576104.

3. Department of Pharmacology, Government medical College, Coorg, Karnataka.


ABSTRACT

To assess efficacy of different classes of drugs in therapy of low back pain. A prospective observational study was carried out over a period of 12 months in which a total of 300 patients with low back pain were enrolled and divided equally into three groups – group 1 (NSAIDs), group 2 (muscle relaxant ±NSAIDs) and group 3 (muscle relaxant ± NSAIDs ± neurotropic drugs). Efficacy of drugs was assessed using oswestry low back disability questionnaire at baseline, 3 weeks and 6 weeks, and the disability index was calculated. There was a male predominance in the study population with a mean age of 39.76 ± 9.40 years. Mean percentage reduction in disability index was maximum in group 2 (54.66±9.85), followed by group 3 (51.33 ± 6.95) and group 1 (46.78 ± 10.12). A significant inter-group difference (p<0.05) was found. NSAIDs with muscle relaxants are more efficacious for low back pain as compared to other combinations.

Keywords: Low back pain, NSAIDs, muscle relaxant, neurotropic drugs


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