Mon, 18 Dec 2017

Anti Nociceptive and Anti Inflammatory Activity of Scheilchera oleosa(lour) Oken Bark

M. Lakshmi Santha1*, P. Kanchana1, CH Supriya1

1. Nirmala college of Pharmacy, Atmakuru, Mangalagiri, Guntur Dt. A.P 522 503, India.


ABSTRACT

Schleicheraoleosa is (Lour.) Oken belonging to the family Sapindaceae. An ethanolic extract of Schleicheraoleosa bark was investigated for its Anti-nociceptic and anti-inflammatory activities in rats and mice. Anti-nociceptic  activity was evaluated  by using the tail immersion, tail flick and hot plate latency assay while the anti-inflammatory test were carried out using the carrageenan induced paw oedema model in rats. Pentazocin was used for analgesic activity and Indomethacin was used for anti-inflammatory activities as standard drugs. The in tail immersion, tail flick and the hot plate latency times were increased with the increase in  doses of 200, 400 & 600 mg/kg significantly. . Similarly, for the carrageenan induced paw oedema model the result show that the extracts at the doses of 200, 400 & 600 mg/kg significantly (P < 0.001) inhibited the paw oedema in a dose dependent manner. The present study proved that the ethanolic extract of S. oleosa has analgesic and anti-inflammatory activities property.

Keywords: Anti nociceptic activity, Anti-inflammatory activity, Scheilcheraoleosa.


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