Mon, 18 Dec 2017

Method Development and Validation of Forced Degradation Studies of Montelukast Sodium by Using UV Spectroscopy

Sk Mastanamma1*, P.Saidulu1, G.Rambabu1, I.S.Tejaswini1

1. Department pharmaceutical analysis, Acharya Nagarjuna university-522510, Guntur, Andhra Pradesh, India.


ABSTRACT

A new, rapid, precise, selective and sensitive validative forced degradative UV spectroscopy method was developed for estimation of Montelukast sodium in bulk and pharmaceutical formulation in the developed method, the absorbance was measured at  272.19nm.the drugs obeyed the Beer’s law in the  concentration range of 30-150μg/mL. Accuracy studies of the method were determined by recovery studies and were found to be 99.9 for Montelukast sodium. It can be used for routine analysis of drug in bulk and in pharmaceutical formulation.

Keywords: forced degradation studies, Montelukast sodium,validation.


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