Mon, 18 Dec 2017

Enhancement of Water Solubility and Dissolution of Water Insoluble Drug Telmisartan by a Novel Powder Solution Technology

Ragini karra1, Anitha kakkerla2*,Raju jukanti3

1. Department of Pharmaceutics, Vaagdevi Institute of Pharmaceutical Sciences Bollikunta, Warangal, Telangana, India.

2. Deparment of Pharmaceutics, Jayamukhi Institute of pharmaceutical sciences,Warangal,Telangana,India.

3. Drug inspector.


ABSTRACT

The objective of the present study was to enhance the dissolution profile, absorption efficiency of water insoluble drugs like Telmisartan. A novel “Powder Solution Technology” involves absorption and adsorption efficiency, which makes use of liquid medications admixed with suitable carriers and coating materials and formulated into a free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of carrier and coating material ratio from 15:1 to 5:1. Avicel ® PH 102 was showing acceptable flow properties compared with Avicel ®PH 200. Higher dissolution rates were observed in optimized liquisolid formulation containing Poly ethylene glycol 400 and Avicel ®PH 102 compared with marketed product (SARTAN® 20mg tablets). Poly ethylene glycol 400 was showing highest solubility compared with poly ethylene glycol 200, propylene glycol and glycerin.The crystalline state of telmisartan drug state was changed to amorphous state due to liquisolid formation and was confirmed by both X-ray diffraction and Fourier transform infrared spectroscopy results, this transition occur as the drug is in solution form. Additionally, increasing the wetting properties and subsequent surface area of the drug available for dissolution.

Keywords: Liquisolid tablets, Telmisartan, Polyethylene glycol, Dissolution, Powder solution Technology.


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