Mon, 18 Dec 2017

Synthesis & antibacterial activities of 1-phenyl-5-(1H-pyrrol-1yl)-1H-pyrazole-4-carboxilic acid N’-acyl hydrazides

Laxmikant S Pavase1, Prashant P Dixit2, B R Chaudhari 3, Dhananjay V Mane*1

1. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad Maharashtra, India, 431004.

2. Department of Microbiology, Dr. Babasaheb Ambedkar Marathwada University, Sub campus, Osmanabad, Maharashtra India, 431501.

3. JES's Z B Patil college, Dhule. Maharashtra.


ABSTRACT

A Novel series of 1-phenyl-5-(1H-pyrrol-1yl)-1H-pyrazole-4-carboxilic acid hydrazide derivatives were prepared by a 4 step course of action starting with Phenyl Hydrazine and 2-(1-ethoxyethylidine)malononitrile, with good yields and simple reaction condition. Synthesized compounds were test for their antibacterial activities. The structures were confirmed by ES-MS, NMR analysis.

Keywords: phenyl hydrazine, pyrazole-4-carboxilic acid, Clauson-Kass procedure, hydrazide, antibacterial activity

 


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