Mon, 18 Dec 2017

Formulation and Evaluation of Tinidazole Microspheres by Using Eudragit S100, HPMC 6000 and HPC 1000 Polymers

Mohammed Hafeez Khan1*, Mohammed Sarddam1, Mohammed Mujeeb Ali1, Mohammed Younus1, Shaik Almas1, P.Sireesha1

1. AZAD College Of Pharmacy,Moinabad,R.R.District,Telangana,India-501504.


ABSTRACT

The aim of the present study is to prepare Tinidazole microspheres by using different polymers. Microspheres were prepared by solvent evaporation method by using various polymers. Formulation is optimized on the basis of acceptable microspheres properties and in-vitro release. In order to obtain best optimized product, 6 different formulations were developed. Different polymers like Eudragit S100, HPMC 6000 and HPC 1000 were taken as variables. Particle size analysis, Shape and Surface Morphology, Flow properties, Degree of swelling, Drug entrapment efficacy, Invitro drug release study were studied as response variables. The different physical properties showed best comparable results with drug. But higher percentage of drug release was observed when the formulation contained Eudragit S 1000 in 1:1 ratio(f3) compared to other formulations. The formulation contained Eudragit was selected as optimized product.

Keywords: Tinidazole, HPMC, HPC, Eudragit.


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