DOI: 10.21276/ajptr
Tue, 16 Oct 2018

Enhancement of Solubility and Oral Bioavailability of Poorly Soluble Drug Rilpivirine by Novel Self Emulsifying Drug Delivery System

V Vijay Kumar*1, 2, J Raju1, D V R N Bhikshapathi3, K Janaki3

1. Jawaharlal Nehru Technological Univercity, Kukatpally, Hyderabad-500072, Telangana, India.

2. Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda-506001, Telangana, India.

3. Vijaya College of Pharmacy, Hayath Nagar, Hyderabad-501511, Telangana, India.


Aim of present study was to develop self emulsifying drug delivery system (SEDDS) for enhancement of solubility, dissolution rate and oral bioavailability of model drug Rilpivirine. Fifteen formulations were prepared using different oils, surfactants and co-surfactants. A pseudo ternary phase diagram was constructed to identify the self-micro emulsification region. Further, the resultant formulations were investigated for clarity, phase separation, drug content, % transmittance, globule size, freeze-thaw stability and in vitro dissolution studies. On the basis of dissolution profile and other above mentioned studies, F5 was found to be the best formulation of Rilpivirine SEDDS which contains Captex 355(Oil), Kolliphor RH 40 (Surfactant) and PG (Co-surfactant). In vivo studies revealed that the oral bioavailability of Rilpivirine from SEDDS was 2.2-fold higher compared to that of pure Rilpivirine suspension in rats, suggesting a significant increase (p<0.05) in oral bioavailability of Rilpivirine from SEDDS formulation.

Keywords: Rilpivirine, SEDDS, Captex 355, Solubility, Bioavailability studies.

[PDF]   Viewed: 1745   Downloaded: 153
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter