Mon, 18 Dec 2017

A Comparative Assessment of Solid Dispersion and Surface Solid Dispersion Technique to Improve Solubility of Simvastatin

Rezaur Bin Islam1, Md. Abdullah Al Masum2*, Md. Mofazzal Hossain3, Anjuman Ara Alam1, Florida Sharmin1, S.M. Ashraful Islam1

1. Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh

2. Research & Development Formulation Department, Incepta Pharmaceuticals Ltd, Savar, Dhaka, Bangladesh

3.Department of Pharmacy, University of Information Technology and Sciences, Baridhara, Dhaka-1212, Bangladesh


ABSTRACT

Practically water insoluble Simvastatin has been accused for being poorly absorbed from gastro intestinal tract. With an aim to improve the solubility and dissolution characteristics of the drug, solid dispersion and surface solid dispersion were prepared by using different water soluble and insoluble carrier at different ratio. Dispersions were made by solvent evaporation technique and undergo drug content test, compatibility by FT-IR, DSC thermal study and in vitro drug release study. FT-IR and DSC thermographs showed the compatibility of the drug and carrier in the incorporated ratio. All the preparations were found to improve the dissolution behavior of Simvastatin significantly compare to the binary physical mixtures and the pure drug. The suitability of solid dispersion and surface solid dispersion technique was evaluated. Also the efficacy of the carriers to improve the dissolution behavior was compared. Tablets were formulated by incorporating dispersions and were subjected to various physical tests including thickness, diameter, hardness, average weight and disintegration time. Their release pattern was compared with compressed matrix of drug and two brand products available in Bangladesh market. Their drug release pattern was further characterized with mean dissolution time (MDT), fractional dissolution time (T50% and T80%) and percent dissolution efficiency. Tablets made of dispersion with HPMC, sodium starch glycolate and croscarmellose sodium were found to have better release rate and extent than the drug and the brand products.

Keywords: Phase homogenization; Release exponent; Mean dissolution time; Dissolution efficiency; Surfactant. 


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