Sat, 16 Dec 2017

Resurgence of Penfluridol: Merits and Demerits

Ranjan Bhattacharyya1*, Rajarshi Bhadra2, Utpal Roy3, Sumita Bhattacharyya4, Jayanta Pal3, Siddhartha Shankar Saha5

1. MD, DNB, PhD trainee, Asst Professor & HOD, Dept of Psychiatry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India.

2. MD. Asst Professor, Dept of Pharmacology, Icare Institute of Medical Science & Research & Dr Bidhan Ch Roy Hospital, Haldia, West Bengal, India.

3. MD. Asst Professor, Dept of Anesthesiology, Murshidabad Medical College & Hospital, Berhampore, West Bengal, India.

4. DDVL, Senior Resident, Dept of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, India.

5. MD. Senior Resident, Dept of Psychiatry, Murshidabad Medical College & Hospital, Berhampore, West Bengal, India.


ABSTRACT

Penfluridol is oral long acting depot antipsychotic introduced in 1970s. The re-emergence of the molecule in the practicing field draws attention of clinicians. The systematic search and review of literature done in order to find current perspectives of use of Penfluridol. Systematic search of prospective clinical research studies has been done. Cochrane Database review of twenty-seven studies done with a total of 1024 patients revealed that penfluridol was superior to placebo in improvement in clinical global impression and reduces the need of additional antipsychotic. Indications of penfluridol include acute psychosis, chronic schizophrenia and Tourette’s syndrome. The notable adverse effects include orthostatic hypotension, osteoporosis leading to fracture in elderly, extra pyramidal side effects and QT prolongations with arrhythmia. Most of the studies were done in 1970s and 1980s when the proper conduct of clinical trials were not established.

Keywords: Penfluridol oral depot, extrapyramidal symptoms, resurgence, adverse effects, Cochrane review.


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