DOI: 10.21276/ajptr
Mon, 22 Jul 2019

Formulation and In-Vitro Evaluation of Sustained Release Tablets Using Natural Polymers

Bhagyashree Tulashidas Chothe1*, Prashant Suresh Devmore1, Maya Desai1, Pravin S. Waghchoure1

1. Govindrao Nikam College of Pharmacy, Sawarde. Chiplun.


The current work deals with the formulation and development of sustained release tablets of Aceclofenac using natural polymers. Anacardium Occidentale (Cashew) gum and xanthan gum were used as a sustained release polymers. Literature survey has revealed that Anacardium Occidentale (Cashew) gum has been used as a pharmaceutical excipient, namely: as a binding agent in tablet formulations, emulsifying agent in emulsions, suspending agent in suspensions and mucoadhesive in mucoadhesive tablet. In this present study we tried to explore its drug release control properties. Aceclofenac drug was used as model drug and xanthan gum was used alone and in combination with cashew gum. Collected cashew gum was purified and checked for its purity by determination of microbial load. Different formulations were set by taking different concentrations of cashew gum, xanthan gum and combinations of both the gums. Tablets were prepared using wet (non-aqueous) granulation method. The flow properties of the granules were evaluated (angle of repose, bulk density, taped density, Car’s index, Hausner’s ratio) and the physical properties of the compressed tablets, namely dimensions, uniformity of weight, hardness, friability and dissolution rate were determined. All results obtained from these tests were found to be within permissible limit. The granules had good flow properties as evidenced by their Hausner’s ratio and Carr’s index values. From the overall result obtained and drug release profile we can conclude that cashew gum can be used as sustained release polymer in sustained release tablet.

Keywords: Aceclofenac, Anacardium Occidentale, sustained release.

[PDF]   Viewed: 966   Downloaded: 122
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter