Mon, 18 Dec 2017

Formulation and Evaluation of Sustained Release Matrix Tablet of Ondansetron Hydrochloride

Santosh Girani1*, Mayudin shumra1, Vishwanath Arakeri1, Manjunath halkeri1, Mahantesh kavatekar1, Ajay Shahpur1

1. Department of Pharmaceutical Technology, BLDEA’s College of Pharmacy, BLDEA’s Hospital Campus, Bijapur, Karnataka, India.


ABSTRACT

In the present study, an attempt was made to prepare and evaluate matrix tablets of Ondansetron HCl using HPMC, EC and Eudragit for Sustained release of Ondansetron HCl. The matrix tablets were prepared by wet granulation method. All the formulations are evaluated for the Hardness, Friability, Weight variation, Drug Content, In-Vitro Drug Release. The weight variation and drug contents of all the tablets were found to be uniform with the low SD values. The FTIR study indicated that the drug is stable in the formulations. The prepared matrix tablets were capable of releasing the drug for 12 hours depending upon the formulation variables. The tablets prepared with HPMC and Eudragit combination have shown higher drug release Drug release mechanism followed non-Fickian transport from both the polymers matrices. The drug released from the formulation is depends on the concentration of the polymers.

Keywords: Sustained Release, Matrix tablet, Ondansetron HCl, HPMC K-100, EC, Eudragit.


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