Sat, 16 Dec 2017

Formulation and Evaluation of Ketoconazole Nanoemulsion Gel for Topical Delivery

Ravi Shankar1*, Vishnu Tiwari1, Chandra Prakash Mishra1, Chandra Kala Singh1, Dharampal Sharma2, Sandhya Jaiswal3

1. Rajasthan Pharmacy College Affiliated to Rajasthan University of Health Science, Bhankrota, Jaipur, Rajasthan, India, 302026.

2. Oniosome Healthcare Pvt. Ltd., Phase 8B, Mohali Punjab, India, 160071.

3. A.S.B.A.S.J.S Memorial College of Pharmacy, Affiliated to Punjab Technical University, Bela Ropar, India, 140111.


ABSTRACT

The aim of present investigation was to develop nanoemulsion gel of ketoconazole for topical delivery and comparison with the marketed preparation. Ketoconazole, BCS class II antifungal agent with broad spectrum activity is a poorly soluble and highly permeable drug. Due to its poor solubility, it is incompletely absorbed after oral dosing and bioavailability varies. The drug efficacy of topical formulation can be limited by instability due to its poor solubility in the vehicle and low permeability. Therefore, to overcome these shortcomings of conventional system nanoemulsion have been used as drug carrier in topical treatment of fungal infection, especially in dermatology. Pseudo-ternary phase diagram was constructed on triplot software to identify nanoemulsion area using different concentrations of oil, Smix (surfactant and co- surfactant) and water. 2% Carbopol 980 as gelling agent and 0.5% DMSO as permeation enhancer was used in topical gel formulation. The formulations was characterized on the basis of pH, drug content, viscosity and in-vitro diffusion study. The optimized formulation was found to have pH 7.4 and drug content 98.90%. In-vitro diffusion study of nanoemulsion gel showed 80.375% release within 8 hrs. Drug release of ketoconazole nanoemulsion gel when compared with marketed formulation showed 80.375% release within 8 hrs as compare to 52.125% for marketed preparation (Ketoconazole cream 2%, H&H Pharmaceutical). So, it is concluded that by incorporating ketoconazole nanoemulsion in topical gel provided sustained release along with improved solubility and permeability.

Keywords: Topical Delivery, Permeability, Permeation Enhancer, In-vitro, Diffusion Study.


[PDF]  Viewed: 1916  Downloaded: 327
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter