DOI: 10.21276/ajptr
Sun, 21 Jul 2019

Formulation and Evaluation of Cefpodoxime Proxetil Fast Dissolving Film

Chandra Kala Singh1*, Vishnu Tiwari1, Chandra Prakash Mishra1, Ravi Shankar1, Dharampal Sharma2, Sandhya Jaiswal3

1. Rajasthan Pharmacy College, Affiliated to Rajasthan University of Health Science, Bhankrota, Jaipur, Rajasthan, India, 302026.

2. Oniosome Healthcare Pvt. Ltd., Phase 8B, Mohali Punjab, India, 160071.

3. A.S.B.A.S.J.S Memorial College of Pharmacy, Affiliated to Punjab Technical University, Bela Ropar, India, 140111.


The purpose of this research work was to formulate fast dissolving film of cefpodoxime proxetil for oral delivery in order to improve oral bioavailability of drug with poor solubility. Cefpodoxime proxetil (CP) is the drug candidate belonging to BCS class IV with poor solubility and poor permeability is and limited oral bioavailability, an orally administered, extended spectrum, semi-synthetic β- lactum antibiotic of cephalosporin class. To improve oral bioavailability, cefpodoxime proxetil nanosuspension was prepared using solvent-antisolvent precipitation technique. Nanosuspension was characterized on the basis of drug concentration in organic phase, temperature, solvent-antisolvent ratio and the time period of stirring on the particle size systematically. Particle size and zeta potential of nanosuspension was observed at 755.6nm and −22.6mV, respectively. Solvent casting method be used in the formation of film, utilizing HPMC E50 as film former, PEG 400 as plasticizer and tween 80 as surfactant. The optimized fast dissolving film formulation F1 showed uniformity of weight (0.091mg), folding endurance (149) drug content uniformity (99.5%), surface pH (6.8) disintegration time (32 seconds in 6.8 PB) and in- vitro drug release 94.2% in 7 min. So, it is concluded from comparison studies between fast dissolving film (FDF) containing pure drug and nanosuspension, fast dissolving film containing cefpodoxime proxetil nanosuspension gives faster and high drug release.

Keywords: Nanosuspension, Bioavailability, Solubility, Fast Dissolving Film.

[PDF]   Viewed: 1534   Downloaded: 167
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter