Sat, 16 Dec 2017

Simultaneous UV Spectrophotometric Method for Estimation of Albendazole and Levamisole Hydrochloride in Tablet Dosage Form

Deepali Arun Jadhav1*, Snehalatha Boddu1, Sarika K. Kadam1, Vedang Kinjwadekar1.

1. Oriental College of Pharmacy, Sector-2, Sanpada, Navi Mumbai 400 705, Maharashtra, India.


ABSTRACT

A simple and sensitive spectrophotometric method for the determination of albendazole and levamisole hydrochloride in pharmaceutical dosage forms has been developed. The absorption maxima were found at 295nm for albendazole and 213 nm for levamisole hydrochloride using ammonium dihydrogen phosphate: methanol as solvent. Beer's law was obeyed for both the drugs in the concentration range of 5-25 for albendazole with correlation coefficient 0.998 and 2-10 for levamisole hydrochloride with correlation coefficient 0.997. The limits of detection for albendazole and levamisole hydrochloride were found to be 0.305µg/mL and 0.732µg/mL respectively and the limits of quantitation were 0.924µg/mL and 2.2µg/mL respectively. Accuracy of the method verified by performing recovery using simultaneous equation method and found to be 98 to 99.5%w/w for albendazole and 97.97 to 99.55 %w/w for levamisole hydrochloride. %RSD of repeatability and intermediate precision studies were found to be <2 for both the drugs. Ruggedness of the method was checked by changing analyst and instrument used. In both the cases, the %RSD was found to be less than 2.

Keywords: Simultaneous, Spectrophotometry, albendazole, levamisole hydrochloride, Beer’s law.


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