Mon, 18 Dec 2017

Diuretic and Hepatoprotective Activity of Aqueous-Alcoholic Combined Extract of Acacia Sinuata Pods and Bark

Satyanarayana Dammavalam1*

1. ASN Pharmacy College, Burripalem road, Tenali, Guntur District, Andhra Pradesh.


ABSTRACT

The current study deals with the investigation of diuretic and hepato protective activity of aqueous alcoholic extract of Acacia Sinuata bark and pods. The method and procedure for diuretic activity is followed by Lipschitz et al. and the method for hepato protective activity is followed by syed mansoor ahamed et al. The present indicates regarding the chemical constituents present in the Acacia Sinuata pods and the bark extract. The preliminary phyto-chemical investigation showed the presence of alkaloids, flavonoids, terpenoids, saponins, glycosides, tannins and phenolic compounds in an aqueous alcoholic extract. The result obtained from the diuretic activity indicates the increased urine output and the increased quantities of sodium, potassium and calcium levels in collected urine. The result obtained from the hepato-protective activity indicates that the dose of 500mg/kg possessed significant hepatoprotective activity. It shows that saponins, glycosides, present in this extract may be possibly responsible for the pharmacological action.

Keywords: Aqueous alcoholic extract, saponins, glycosides, diuretic, tannins.


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