Sat, 16 Dec 2017

Synthesis, Molecular Properties Prediction and Biological Evaluation of Benzothiazole Trithiocarbamate Derivatives

Akula Naga Venkata Sunitha1, Seeta Sharada1, Gambiraopet Alekya1, Oleti Navneetha1, Sandala Anuradha Bai1, Tangeda Saritha Jyostna1*

1. Medicinal Chemistry Division, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Hyderabad-500017, India.


ABSTRACT

In the present investigation, a series of novel benzothiazole trithiocarbamates have been synthesized. It deals with the design and calculation of Molecular Properties, Drug likeness, Lipophilicity and solubility parameters using Molinspiration, Molsoft softwares. Toxicity parameters were calculated using Osiris software. All the compounds are non-toxic, fulfill the solubility requirements and passing oral bioavailiability criteria. The compounds were synthesized and characterized by IR, 1HNMR, Mass spectral analysis followed by antimicrobial screening. Most of the synthesised compounds (4a-4g) were found to be on conformity with Lipinski’s “Rule of Five” and other parameters, for their onward screening for antimicrobial activity as oral active drugs.

Keywords: Benzothiazole, Trithiocarbamates, Molinspiration, Molsoft, Osiris, Antimicrobial activities.


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