Thu, 23 Nov 2017

Biomarkers In Disease Diagnosis

Vani Mamillapalli1*, Harathi Pothanaboina1, Padma Latha Khantamneni2

1. Department of Pharmacognosy and Phyto Chemistry, Vijaya Institute of  Pharmaceutical Sciences for Women, Enikepadu, Viayawada, Pin: 521108, Krishna District, Andhra Pradesh, India.

2. Department of Pharmacology, Vijaya Institute of  Pharmaceutical Sciences for Women, Enikepadu, Viayawada, Pin: 521108, Krishna District, Andhra Pradesh, India.


ABSTRACT

Biomarkers provide a dynamic and powerful approach to understanding the spectrum of disease with applications in observational and analytic epidemiology, randomized clinical trials, screening, diagnosis and prognosis. Biomarker is defined as alteration in the constituents of tissues or body fluids, these markers offer the means for homogeneous classification of a disease and risk factors, and then can extend our base information about the underlying pathogenesis of disease. A prerequisite for the clinical use of biomarker is elucidation of the specific indication, standardization of analytical methods, characterization of analytical features, incremental yield of different markers for given clinical indications. Biomarkers can also reflect the entire spectrum of disease from the earliest manifestations to the terminal stages. The major use of biomarkers has been employed  in clinical investigation. The article features biomarkers in drug development and in disease diagnosis.

Keywords: Disease diagnosis, Biomarker, Drug development, Clinical investigation.


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