Thu, 23 Nov 2017

Sphingosomes: A Novel Approach For Vesicular Drug Delivery System

M. Vasavi Chandrika1*, G. Sindhu Manasa1, P. Likitha sri mounica1, P. Hima Varsha1, P. Bhavya sri1

1.Department of Pharmaceutics, St.Ann’s College of Pharmacy, Chirala-523155, India


ABSTRACT

Sphingosomes is bilayer vesicles in which an aqueous volume is entirely enclosed by membrane lipid bilayer mainly composed of natural or synthetic sphingolipid. Sphingosomes solve the major drawback of vesicle system(liposomes, niosomes) like less stability, less in vivo circulation time, low tumor loading efficacy in case of cancer therapy. The outcome of this review is that Sphingosomes represents a promising vesicular drug delivery system to delivers therapeutic compounds for a range of possible application. Sphingosomes are clinically used delivery system for chemotherapeutic agent, biological macromolecule and diagnostics. Due to flexibility in size and composition, different types of Sphingosomes have been developed.

Keywords: Sphingosomes, Lipid bilayer, Vesicular drug delivery, sphingolipid, cholesterol.


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