Thu, 23 Nov 2017

An Efficient Synthesis of Disubstituted Pyrazoles From 2-Propyn-1-ol Through Propargyl Hydrazides

N. Srinivasan1*, B.Venkateswara Rao1,  J. D. Lilakar1,  Y.L.N. Murthy1, P. Mahesh1

1.Department of Organic Chemistry, Andhra University, Visakhapatnam– 531001, India


ABSTRACT

An efficient synthesis process access to disubstituted pyrazoles have been demonstrated from 2-propyn-1-alcohols using an effective catalyst Polymer bound pTSA. This conversion proceeds via an acid catalyzed propargylation of N,N-diprotected hydrazines followed by base-mediated cyclization to furnish 3,5-Disubstituted-1H-pyrazoles in optimum yields.

Keywords: 2-Propyn-1-ol, Cyclization, Substituted Pyrazole, Heterocyclic moieties, and coupling reactions.


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