DOI: 10.21276/ajptr
Tue, 19 Feb 2019

An Efficient Synthesis of Disubstituted Pyrazoles From 2-Propyn-1-ol Through Propargyl Hydrazides

N. Srinivasan1*, B.Venkateswara Rao1,  J. D. Lilakar1,  Y.L.N. Murthy1, P. Mahesh1

1.Department of Organic Chemistry, Andhra University, Visakhapatnam– 531001, India


An efficient synthesis process access to disubstituted pyrazoles have been demonstrated from 2-propyn-1-alcohols using an effective catalyst Polymer bound pTSA. This conversion proceeds via an acid catalyzed propargylation of N,N-diprotected hydrazines followed by base-mediated cyclization to furnish 3,5-Disubstituted-1H-pyrazoles in optimum yields.

Keywords: 2-Propyn-1-ol, Cyclization, Substituted Pyrazole, Heterocyclic moieties, and coupling reactions.

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