Thu, 23 Nov 2017

Prostate specific antigen (PSA) and sarcosine levels In Patients With Benign Prostatic Hyperplasia (BPH) Disorders In Sokoto, Nigeria

Nnamah1*, NK,2Anaja, PO, 3Mungadi, IA and 4Bilbis,LS,5Dallatu,MK

1.Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikwe University, Nnewi,

2.Department of Chemical Pathology, Faculty of Medicine, Ahmadu Bello University, Zaria,

3.Department of Surgery, Faculty of Clinical Sciences, Usmanu Danfodiyo University,Sokoto,

4.Departmenty of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, Sokoto.

5.Department of Chemical Pathology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria


ABSTRACT

Prostate specific antigens occurs in serum in different molecular isoforms, and serum levels of these isoforms have been introduced as adjuncts for prostate disorder screening to reduce misdiagnosis. Little data exist on the use of these tests for screening patients with BPH . In the current study, serum level of total, free and complex  prostate specific antigen (tPSA,fPSAand cPSA) isoforms and serum sarcosine were evaluated in 200 BPH patients and 200 matched controls. tPSA level  was 15.13±1.15 ng/ml in BPH patients and 2.75±0.22 ng/ml in controls. fPSA was 2.81±0.16 ng/ml in BPH patients and 0.72±0.03 ng/ml in controls. cPSA was 12.31±1.05 ng/ml in BPH patients and 0.72±0.03 ng/ml in controls. Serum sarcosine was 118.70±1.80 nmol/dl in BPH patients and 64.94±0.81 nmol/dl in controls. The differences between patients and controls in all the analytes are significant (<0.05). In conclusion, the evaluation of these analytes may improve BPH diagnosis and reduce the number of prostatic biopsies in patients with BPH.

Keywords: Prostate Specific Antigen( PSA), PSA Isoforms, sarcosine and Benign Prostatic Hyperplasia (BPH) diagnosis.


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