Thu, 23 Nov 2017

Synthesis, Cytotoxic, Antioxidant and Anti-Inflammatory Activity of 3-((3-((6-Benzoyl-1H-Benz [D]Imidazol-2-YL) Amino)-5-Mercapto-4H-1,2, 4-Triazol-4-YL) Imino)Substituted Indol-2-Ones

B.Shoba rani1*, K. Blessi Priyanka1, G.Sammaiah1

1.University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, 506009


ABSTRACT

In the present study novel series of 3-((3-((6-benzoyl-1H-benz[d]imidazol-2-yl) amino)-5-mercapto-4H-1, 2, 4-triazol-4-yl)imino)substituted indolin-2-ones have been synthesized in good yields and characterized by IR, NMR and Mass spectral analyses. Compounds were evaluated for their preliminary in vitro cytotoxic activity against HCT-116 (colon), MCF-7 (breast), HeLa (cervical) and HepG2 (hepatocellular) cancer cell lines by standard MTT assay method, antioxidant activity by standard DPPH assay method and also were screened for  in vitro anti-inflammatory activity.

Keywords: Benzimidazole, Isatin, Cytotoxic, Anti-Inflammatory, Antioxidant.


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