DOI: 10.21276/ajptr
Tue, 19 Feb 2019

Determination of Hypoglycaemic Activity from Various Plant Extracts in Normal and Alloxan Induced Diabetic Rats

Syeda Rana Nikhat1* , V. Rajesh Babu1

1.Department of Pharmacy, MESCO College of Pharmacy, Hyderabad, Telangana State.


The present study is undertaken to explore the effects of aqueous, alcoholic, chloroform and Petroleum ether extracts of Hibiscus rosa sinensis(HS), Aegle marmelos(AM), and Jatropha curcas(JC) on blood glucose level in both normal and alloxan induced diabetic rats.  In this single dose study, extracts are prepared by Maceration process with different solvents. Extracts of HS, AM, JC  was given once orally in different doses .The effect of extract was studied in normal rats, alloxan (150mg/kg, i.p.) induced diabetic rats and glucose fed normal rats by measuring fasting blood glucose level at different intervals. The extracts exhibited significant (p<0.01) antidiabetic activity in normal fasted rats and alloxan induced diabetic rats. The present study showed that aqueous extract of HS, AM, JC has potent antidiabetic effect in alloxan induced rats and Development and evaluation of tablet formulations showing significant activity and to compare these effects with Glibenclamide Standard Marketed product. 

Keywords:  Diabetes mellitus, Hibiscus rosa sinensis(HS), Aegle marmelos(AM), Jatropha curcas(JC),  Antidiabetic, Alloxan, chloroform, petroleum ether, Alcohol.

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