Thu, 23 Nov 2017

Determination of Hypoglycaemic Activity from Various Plant Extracts in Normal and Alloxan Induced Diabetic Rats

Syeda Rana Nikhat1* , V. Rajesh Babu1

1.Department of Pharmacy, MESCO College of Pharmacy, Hyderabad, Telangana State.


ABSTRACT

The present study is undertaken to explore the effects of aqueous, alcoholic, chloroform and Petroleum ether extracts of Hibiscus rosa sinensis(HS), Aegle marmelos(AM), and Jatropha curcas(JC) on blood glucose level in both normal and alloxan induced diabetic rats.  In this single dose study, extracts are prepared by Maceration process with different solvents. Extracts of HS, AM, JC  was given once orally in different doses .The effect of extract was studied in normal rats, alloxan (150mg/kg, i.p.) induced diabetic rats and glucose fed normal rats by measuring fasting blood glucose level at different intervals. The extracts exhibited significant (p<0.01) antidiabetic activity in normal fasted rats and alloxan induced diabetic rats. The present study showed that aqueous extract of HS, AM, JC has potent antidiabetic effect in alloxan induced rats and Development and evaluation of tablet formulations showing significant activity and to compare these effects with Glibenclamide Standard Marketed product. 

Keywords:  Diabetes mellitus, Hibiscus rosa sinensis(HS), Aegle marmelos(AM), Jatropha curcas(JC),  Antidiabetic, Alloxan, chloroform, petroleum ether, Alcohol.


[PDF]  Viewed: 373  Downloaded: 83
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter