DOI: 10.21276/ajptr
Tue, 19 Feb 2019

Cardio Protective Efficacy of Seeds of Spermacoce Hispida Linn on Lysosomal Enzymes and Membrane Bound ATPases in Cardiotoxic Rats

Dhevi R1*, Elango. V2

1.      Research scholar, Department of Siddha medicine, Tamil University, TN, India.

2.Assistant Professor, Department of Siddha medicine, Tamil University, TN, India


Spermacoce hispida possesses significant anti-oxidant and cardioprotective activities. This manuscript reveals the preventive potential of seed extract on lysosomal damage in isoproterenol induced myocardial infarction (MI) in rats. Two different doses of the plant extract such as 100 and 200 mg/kg body weight was used to prove the cardioprotective effect against 100mg/kg body weight of isoproterenol (ISO). The activities of lysosomal enzymes in the heart of ISO- induced MI rats were increased significantly.  Pretreatment with hydro alcoholic extract of seeds of Spermacoce hispida prevented the changes in the levels of lysosomal enzymes in isoproterenol induced MI rats. The activity of enzymes like β –D- Galactosidase, β –D- Glucuronidase, N-Acetyl β-D –glucoseaminidase, Cathepsin D and ATP ases are found to be increased in heart homogenate in diseased rats against normal animals.

Keywords: anti-oxidant, cardioprotective, isoproterenol, lysosome

[PDF]   Viewed: 778   Downloaded: 84
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter