Thu, 23 Nov 2017

Simultaneous Estimation of Aceclofenac and Esomeprazole Sodium in Bulk By RP-HPLC

Divya Narla1, Bandam Poojitha1

1. Department of Pharmaceutical Analysis, Aditya College of Pharmacy,Surampalem, E.G.Dt., Andhra Pradesh.


ABSTRACT

A simple, accurate, precise and specific RP-HPLC method has been developed for the simultaneous estimation of Aceclofenac and Esomeprazole Sodium in bulk. Chromatographic analysis was carried out on C18 column ( 250mm × 4.6mm, 5µm). Mobile phase used is a homogenous mixture of ACN: Methanol in the ratio of 50:50 v/v. The detection was carried out at 285nm. The retention times were found to be 3.00 and 4.41 min for Aceclofenac and Esomeprazole Na respectively. Both the drugs showed linearity in the range of 30 – 70mcg/ml. The correlation coefficient was found to be 0.99 and 0.992 for Aceclofenac and Esomeprazole Na respectively. The developed method was validated as per ICH guidelines.

Keywords: Aceclofenac, Esomeprazole Sodium, RP-HPLC, Validation, Simultaneous estimation.


[PDF]  Viewed: 630  Downloaded: 84
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter