Thu, 23 Nov 2017

Novel Drug Binder From Biomaterials: Synthesis and Characterization

Nisarg K. Prajapati1, N. K. Patel2, Vijaykumar Sinha1*

1.Industrial Chemistry Department, V.P. & R.P.T.P. Science College, Vallabh Vidyanagar – 388120, Anand, Gujarat – India.

2. Institute of Science & Technology for Advanced Studies & Research, Vallabh Vidyanagar – 388120, Anand, Gujarat – India.


ABSTRACT

The developments in the field of polymeric superabsorbent over the past decade are presented in the paper. Special attention has been paid to the preparation methods to emphasize the new synthesis strategies developed in the recent years.  Superabsorbent copolymers form as a result of the phase separation during the free radical cross linking copolymerization of sodium acrylate, methyl acrylate and methyl methacrylate monomers in the presence of inert diluents. It has been established that a variety of absorbent structures can be achieved during or after the cross linking by varying the independent parameters of the polymer synthesis, i.e. the degree of the polymer interactions, the amount of the cross linker and the diluents as well as the initiator concentration or the polymerization temperature. The most important reaction parameter to superabsorbent polymer synthesis is a ternary system composed of a polymer network, soluble polymers and low molecular compound. All concentrations of polymeric mass and properties of the monomers of the system change continuously during the cross linking process. Synthetic polymeric hydrogels represent a group of materials, used in various biomedical regulations, and are still developing for new promising applications.  There has been extensive development in the clinical and pharmacological precincts of hydrogels for drug delivery applications but imperative challenges remain. Here we also discuss the current movement in overcoming these challenges, specifically with regards to successfully delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs from hydrogels, and increasing the nature of drugs which can be delivered via hydrogel based approaches.  They have been effectively used as superabsorbent materials and in drug delivery, cell encapsulation and tissue repair due to their high water content and subsequent biocompatibility.

Keywords: Starch, Carboxyl Propyl Starch, CPS-acrylate, CPS-methyl acrylate, CPS-methyl methacrylate.


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