Thu, 23 Nov 2017

Simultaneous Estimation of allopurinol and aceclofenac in bulk drug and pharmaceutical formulation by using UV-visible Spectroscopy method

Rajiv Kumar1*

1. Khalsa College of Pharmacy, Amritsar, Punjab, 


ABSTRACT

The present manuscript describes sensitive, rapid, accurate, and precise spectrophotometric method for simultaneous estimation of allopurinol and aceclofenac in pharmaceutical dosage form. Simultaneous equation method used at 250nm & 273nm as λmax of allopurinol and aceclofenac respectively in 0.1N HCl. Both the drugs follow beer-lamber’s law on the concentration range 2-12µg/ml and 2-24µg/ml respectively for allopurinol & aceclofenac. The mean percentage recovery is 100.01% and 99.4% for allopurinol and aceclofenac respectively by simultaneous equation. The method has been validated as per ICH guidelines. The proposed method effectively applied to bulk drug and pharmaceutical formulation. The accuracy and reproducibility are close to 100% with acceptance range of %R.S.D. The method was successfully applied to pharmaceutical dosage form because no interference was found from excipient. 

Keywords: Simultaneous equation, Validation, Allopurinol, Aceclofenac, Methanol.


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