DOI: 10.21276/ajptr
Tue, 19 Feb 2019

Quantitative Structure-Pharmacokinetic Relationship (QSPkR) Analysis of the Serum Protein Binding Values for Antidiabetic Agents In Humans

Sethi Reeta1, Paul Yash2

1.Shri Jagdish Prasad Jhabarmal Tibrewala University, Jhunjhunu (Rajasthan)

2.Lord Shiva College of Pharmacy, Sirsa (Haryana)


An estimate of Serum protein binding (%SPB) is of paramount importance in assessing the efficacy of drugs used to treat diabetes in patients.  This study was conducted to develop Quantitative Structure Pharmacokinetic Relationship (QSPkR) for the prediction of %SPB in human for congeneric series of 23 antidiabetic drugs, using computer assisted Hansch approach.  The QSPkR correlations were duly analyzed using a battery of apt statistical  procedures and validated using leave-one-out (LOO) approach. Analysis of several hundreds of QSPkR correlations developed in this study revealed high degree of cross- validated coefficients (Q2) using LOO method (p<0.001). The overall predictability was found to be high serum protein binding (%SPB) ( R2=0.8709, F=19.20, S2=93.89, Q2=0.6685, p<0.001). Serum protein binding (%SPB) in  the present QSPkR investigations was found to depend upon electrostatic  and constitutional parameters. Its positive dependence on such descriptors indicates that hydrogen bonding and vander Waals’ interactions play a stellar role in governing protein binding.

Keywords: Quantitative structure pharmacokinetic relationships (QSPkR), Serum protein binding, In Silico ADME, antidiabetic drugs

[PDF]   Viewed: 757   Downloaded: 99
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter