DOI: 10.21276/ajptr
Tue, 19 Feb 2019

An efficient synthesis and characterization of some novel pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives

Dipen K. Sureja1*, Kirtan P. Sanghvi1, Ashish P. Shah1 and Kantilal R. Vadalia2

1.Department of Pharmacy, Sumandeep Vidyapeeth, Po - Piparia, Ta - Waghodia, Vadodara - 391760, Gujarat, India.

2.Atmiya Institute of Pharmacy, Yogidham Gurukul, Kalawad road, Rajkot - 360005, Gujarat, India.


A simple and efficient approach towards single step synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives has been developed by condensation reaction of ethyl ester of 5-amino-1-substituted-1H-pyrazole-4-carboxylate with different aromatic nitriles under acidic conditions. All the newly synthesized compounds were characterized by spectroscopic techniques (IR, NMR and Mass spectra) and elemental analysis.

Keywords: Single step synthesis, ortho amino ester of pyrazole, aromatic nitriles, pyrazolo[3,4-d]pyrimidine derivatives.

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