Mon, 22 Jan 2018

Antioxidant Activity of Oxochromen derivative Isolated From the Stem Bark of T. populnea

Florance EJ1*, Dhayabaran D2, Nandakumar K3

1.Research Scholar, PRIST University, Thanjavur, Tamil Nadu. St. John College of Pharmacy, Yellapur, Warangal, Telangana.

2.QIS College of Pharmacy, Ongole, Andhra Pradesh.

3.Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India


ABSTRACT

A novel antioxidant oxochromen derivative was isolated and characterized from Thespesia populnea stem bark (Linn.) with the evaluation of its in vitro antioxidant activity. The isolated compound was characterized by FTIR, 1H NMR, 13C NMR, and mass spectral technique. The spectral data revealed the structure [(2S,3R,4S,5S,6R)-2-(5,7-dihydroxy-2-methyl-4-oxochromen-6-yl)-4,5-dihydroxy-6-(hydroxyl methyl) oxan-3-yl] 3,4,5-trihydroxybenzoate. Antioxidant activity of the isolated compound was evaluated by DPPH scavenging activity, ABTS scavenging activity and Ferric reducing /antioxidant power assay. Results show that isolated compound from the acetone extract fraction of T. populnea stem bark exhibit better antioxidant activity at lower concentration in all the methods and at higher concentrations they act as prooxidants. In conclusion the present results suggested that the isolated compound could be a potential antioxidant agent for preparing functional foods and nutraceuticals applied in food and pharmaceutical industries.

Keywords: Thespesia populnea, Antioxidant, DPPH, ABTS, FRAP


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