DOI: 10.21276/ajptr
Sat, 18 Aug 2018

A New Stability Indicating RP-HPLC Method for the Assay of Olmesartan In Market Formulations

D.Anitha1 , M.Manoranjani1*

1. Dept. of Chemistry, P.B.Siddhartha College of Arts & Science, Vijayawada, A.P, India.


ABSTRACT

A new stability indicating RP-HPLC method was described for the assay of olmesartan in market formulations. This developed RP-HPLC method was based on high performance liquid chromatographic (HPLC) separation of olmesartan with the use of a reversed phase HPLC column [Kromasil BDS, C18, 100 x 4.6 mm, 5μ] with mobile phase consisting of .01M KH2PO4 buffer (pH-4.5) and acetonitrile in the ratio of 55:45 %v/v at ambient temperature. The flow rate of the mobile phase was adjusted to 1.0mL/min and the injection volume was 10μL. Detection was performed by photodiode array detector at a wavelength of 257nm and the chromatographic runtime was 8 minutes for the analysis. The reliability and analytical performance of the proposed method, including linearity, range, precision, accuracy, detection and quantitation limits, were statistically validated. The proposed method can be adopted apparently for routine quality control analysis of raw materials, formulations and testing

Keywords:  Olmesartan, RP-HPLC, ICH guidelines.


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