Mon, 22 Jan 2018

Synthesis, Characterization and Pharmacological Evaluation of Ester Derivate of Prednisolone

Jyoti Garg1*, Raj Kumar1

1.Department of P.G. Studies & Research in Chemistry, J.V. Jan (P.G.) college, Saharanpur, Chaudhary Charan Singh University, Meerut, 247001, Uttar Pradesh


ABSTRACT

In the present study some novel ester derivates of prednisolone were synthesized as prodrugs and evaluated for their anti- inflammatory activity. This compound was prepared by reacting Ethyl-N-tert-butyloxycarbonylglycinate-protected amino acids. These novel prodrugs were also characterized with the help of usual analytical and spectral techniques (I.R spectroscopy & N.M.R. spectroscopy). These newly synthesized ester derivates of prodrugs were screened for their spectral techniques.  All the above compounds showed significant anti- inflammatory effect at 50 mg/kg p.o. and the experimental data are statistically significant at p< 0.05 level. The pharmacological activities exhibited by synthesized novel compounds have confirmed that they may serve the purpose of being accepted as the novel therapeutic agents as anti-inflammatory agents.

Keywords: Prednisolone; Ester Derivates; Spectral Techniques; Anti- Inflammatory


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