DOI: 10.21276/ajptr
Sun, 21 Jul 2019

Effect of Acetone Root Extract of Canthium parviflorum Lam. in N-Nitroso N-Methyl Urea Induced Mammary Carcinoma in Female Sprague-Dawley Rats

John. D. Milton1*,   M. Alvin Jose2

1. Prist University, Vallam, Thanjavur-613403. Tamil Nadu, India.

2. Swamy Vivekananda College of Pharmacy, Elayampalayam, Tiruchengode-637205. Namakkal District, TamilNadu, India.


The objective of the study was to evaluate the anticancer activity of Acetone root extract of Canthium parviflorum Lam. (ARECP) in N-Nitroso N-methyl urea (NMU) induced mammary carcinoma in female Sprague-Dawley rats. Thirty virgin female Sprague-Dawley rats of 55 day old were divided into five groups (normal control, disease control, ARECP 200 mg/kg, ARECP 400 mg/kg, tamoxifen10 mg/kg) of six animals each. The mammary carcinoma was induced by two intraperitoneal doses of N-Nitroso N-methyl urea (NMU) (50mg/kg/body weight each) in 0.9% Nacl (maintained at 40C) at 55 day of age and 4 week after the prior administration. The drug ARECP was administered in two doses, 200 mg/kg, and 400 mg/kg orally and compared with the oral dose of tamoxifen (10 mg/kg). ARECP 200 mg/kg, 400 mg/kg, and tamoxifen10 mg/kg decreased the tumor incidences by 33.33%, 50%, and 83.33% and the total number of tumors in group by 33.33%, 60% and 93.33% respectively, when compared to the disease control. ARECP 200 mg/kg, 400 mg/kg, and tamoxifen 10 mg/kg decreased the average tumor burden by 65.06%, 92.16% and 95.72% and average tumor volume by 62.25%, 85.18%, and 93.73% respectively, when compared to disease control group. The results concluded that ARECP prevent the mammary carcinogenesis induced by N-Nitroso N-methyl urea in female Sprague-Dawley rats.

Keywords: Mammary Carcinoma, Canthium parviflorum, tamoxifen, N-Nitroso N-methyl urea.

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