DOI: 10.21276/ajptr
Sun, 21 Jul 2019

Formulation, Development and Evaluation of Fast Disintegrating Thin Film of Esomeprazole Magnesium Trihydrate

Sonia Narwal*1, Vipin Saini1

1.M.M.College of Pharmacy, M.M University, Mullana, Ambala-133207, India. Haryana, India.


The objective of present study was to prepare and evaluate orally fast dissolving film of Esomeprazole magnesium trihydrate for the effective management of peptic ulcers to prevent excess amount of acid secretion in the stomach. Drug Esomeprazole was identified using DSC, FTIR and XRD. To improve the water solubility beta cyclodextrin complex of drug in 1:1 milimolar ratio was prepared. Solubility of drug in complex was found to be 7.67±0.52 mg/ml, represents the complex formation between drug and beta cyclodextrin. 21 batches of fast dissolving film of beta cyclodextrin complex were prepared by using different type of film forming agent, different concentration of film forming agent, different type of plasticizers, and different concentration of plasticizer agent. On evaluation, HPMC E15 and propylene glycol was optimized. Most of the films were homogeneous, transparent, colorless, flexible and easily peel out. The prepared films were subjected to characterization for weight variations, thickness, disintegration time, dissolving time, drug release pattern, % moisture loss etc.  On drug release kinetic mode study, optimized fast dissolving film following Higuchi model.  The scanning electron photomicrograph of the film showed smooth surface with some little pores and without any scratches or transverse striations which is an indication of uniform distribution of drug particles and fast disintegration. Films were stored at different temperature did not show any changes in the physical appearance. Clear, transparent and homogeneous films remained throughout the 90 days but at accelerated temperature conditions, some part of film was breakdown during Peeling out.

Keywords:  Esomeprazole Magnesium trihydrate, Oral films, Solvent casting, Propylene glycol, Pharmacokinetics, HPMC E15.

[PDF]   Viewed: 1030   Downloaded: 153
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter