DOI: 10.21276/ajptr
Thu, 21 Jun 2018

Formulation and Evaluation of Floating Bioadhesive Tablets of Nevirapine

Shailaja Pant1*, Ashutosh Badola1, Preeti Kothiyal1

1.Division of Pharmaceutical Sciences, SGRRITS Patel Nagar, Dehradun – 248001, Uttarakhand, India


ABSTRACT

Floating drug delivery system is suitable for NVP as the absorption and solubility of NVP is high at pH<3. The absorption rate of NVP was decreased from upper part to lower part of GIT and from jejunum to descending colon thus the purpose of our study was formulation of floating bioadhesive tablets to increase the retention time of drug in its absorption area and decrease the dosing interval by increasing the bioavailability. The formulations were prepared by polymer such as hydroxyl propyl methyl cellulose (HPMC) and carbopol 934 in different ratio using direct compression technique. The effervescent base sodium bi carbonate and citric acid was used in 7.5% ratio. The present was concluded that the floating-bioadhesive tablets of Nevirapine can increase the gastric residence time as well as bioavailability. Thus better patient compliance can be achieved.

Keywords: Nevirapine, gastric retention, floating, bioadhesion


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