DOI: 10.21276/ajptr
Wed, 27 Mar 2019

Biological Activity Profile of Thiazolidinone Scaffolds Linked to Bioactive Thiazoles: A Review

Aman Bhalla1*, Shiwani Berry1, Shamsher S. Bari1

1.Department of Chemistry & Center of Advanced Studies in Chemistry, Panjab University, Chandigarh - 160 014, India


Thiazolidinones have been explored in both academia and pharmaceutical industry for their wide spectrum of biological applications which include activity against streptomyces species, anti-convulsant, hypoglycemic, antihypertensive agents and therefore, they are useful molecules for drug research and organic chemistry. Thiazolidinone derivatives containing thiazole ring system are also found to possess pharmacological activities such as anticancer, antimalarial, tuberculostatic, anticonvulsant, anti-HIV activity and CNS stimulants. Extensive research in the synthesis and biological evaluation of thiazolidinone substituted heterocycles is well documented and hence, attracted the interest of organic chemist. Therefore, the objective of this review to highlight the biological properties of thiazolidinone derivatives bearing thiazole ring system. The introductory paragraph highlights the significance of the thiazolidinone moiety and is followed by an overview of thiazole heterocycle. In the next section pharmacological properties of thiazolidinone linked thiazole derivatives has been described

Key words: 4-Thiazolidinone, Thiazole, Heterocycles, Biological Activity 

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