Tue, 21 Nov 2017

Microsponge: An augmented drug delivery system

Anupamaa Tiwari1*, Manoj Kumar Mishra1, Ashutosh Shukla1, Sunil Kumar Yadav1

1.Shambhunath Institute of Pharmacy, Jhalwa, Allahabad, Uttar Pradesh-211012, India


ABSTRACT

Microsponges are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles with a large porous surface. Moreover, they may enhance stability, reduce side effects and modify drug release favorably. Microsponge technology has many favorable characteristics, which make it a versatile drug delivery vehicle. Microsponge Systems are based on microscopic, polymer-based microspheres that can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as a gel, cream, liquid or powder. The outer surface is typically porous, allowing a sustained flow of substances out of the sphere. Microsponges are porous, polymeric microspheres that are used mostly for topical use and have recently been used for oral administration. Microsponges are designed to deliver a pharmaceutical active ingredient efficiently at the minimum dose and also to enhance stability, reduce side effects, and modify drug release. The aim of this article is to provide detail about microsponges and the past work done on it.  Microsponge delivery system consisting of a polymeric bead having network of pores with an active ingredient held within. Microsponge was developed to provide controlled release of the active ingredients whose final target is skin itself. Microsponge delivery system can be prepared into conventional dosage forms such as creams, lotions, gels, ointments, and powder and share a broad package of benefits. It holds a promising future in various pharmaceutical applications in the coming years. This review article consists of full detail on microsponge and different types of drug formulated in microsponge.

Keywords: Microsponge, drug delivery, augmentation, marketed products


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