Tue, 21 Nov 2017

A Comprehensive Review On Structural and Biological Activity Relationship of 3-Acetoxyazetidin-2-Ones

Aman Bhalla1*, Dipika Narula1, Shamsher S. Bari1

1.Department of Chemistry & Center of Advanced Studies in Chemistry, Panjab University, Chandigarh - 160 014, India


ABSTRACT

Azetidin-2-ones (β-lactams) have been a mainstay as therapeutics for the treatment of a wide range of bacterial infections. The interest in β-lactams stems from their highly unusual structure-activity profiles towards a genera of pathogenic bacteria. Tremendous efforts have been made in the literature towards the development of novel β-lactam compounds for a study of their biological evaluation. The present review begins with a brief introduction of β-lactam antibiotics. This is preceded by the progress made towards the biological evaluation of a variety of racemic as well as optically active cis- or trans-3-acetoxyazetidin-2-ones. Their application in medicinal field as antifungal, antibacterial, antitumor, anticancer, IMR32 cytotoxic agents and carbonic anhydrase inhibitors is discussed.

Keywords:  3-Acetoxyazetidin-2-ones, antifungal, antibacterial, antitumor, anticancer, carbonic anhydrase inhibitor


[PDF]  Viewed: 185  Downloaded: 50
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter