DOI: 10.21276/ajptr
Wed, 27 Mar 2019

A Comprehensive Review On Structural and Biological Activity Relationship of 3-Acetoxyazetidin-2-Ones

Aman Bhalla1*, Dipika Narula1, Shamsher S. Bari1

1.Department of Chemistry & Center of Advanced Studies in Chemistry, Panjab University, Chandigarh - 160 014, India


Azetidin-2-ones (β-lactams) have been a mainstay as therapeutics for the treatment of a wide range of bacterial infections. The interest in β-lactams stems from their highly unusual structure-activity profiles towards a genera of pathogenic bacteria. Tremendous efforts have been made in the literature towards the development of novel β-lactam compounds for a study of their biological evaluation. The present review begins with a brief introduction of β-lactam antibiotics. This is preceded by the progress made towards the biological evaluation of a variety of racemic as well as optically active cis- or trans-3-acetoxyazetidin-2-ones. Their application in medicinal field as antifungal, antibacterial, antitumor, anticancer, IMR32 cytotoxic agents and carbonic anhydrase inhibitors is discussed.

Keywords:  3-Acetoxyazetidin-2-ones, antifungal, antibacterial, antitumor, anticancer, carbonic anhydrase inhibitor

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