Tue, 21 Nov 2017

Synthesis and Spectral Characterization of N-Phenyl-3-Phenyl-5-Substituted Phenyl Pyrazoline and 4-Phenyl-6-Substituted Phenyl-3,4-Dihydro Pyrimidine-2-one Analogues

S.Selvakumar1*, S.Ravichandran 2, B.Saritha1, T.Bhargavi1

1.Swami Vivekananda Institute of Pharmaceutical Sciences, Vangapally (V), Yadagirigutta (M), Yadadribhongir(Dt), Telangana –508 286, India.

2.P.S.V. College of Pharmaceutical Science and Research, Orappam Village, Bargur (Tk), Krishnagiri (Dt), Tamilnadu –635108, India.


ABSTRACT

The substituted chalcones (C1-5) was prepared by reaction of acetophenone (a) and aromatic aldehydes (b1-5). One series of N-phenyl pyrazoline analogues (K1-K5) were synthesized by reaction of the substituted chalcones (C1-5) with phenyl hydrazine in acidic medium. Another series of 3, 4-dihydropyrimidine-2-one analogues (K6-K10) were synthesized by reaction of substituted chalcones (C1-5) with ethanolic urea in alkali medium. The yield of the synthesized analogues ranged from 62-76%. The structures of the synthesized analogues were verified by FTIR,1H-NMR, mass spectral data and physical analysis. The structures of the synthesized heterocyclics are correlated with the spectral analysis and the synthesized heterocyclics structures are well agreed with the proposed structure.

Keywords: pyrazoline, pyrimidine, chalcones, Infrared spectroscopy, Nuclear Magnetic Resonance  spectroscopy and Mass spectroscopy


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