DOI: 10.21276/ajptr
Sun, 24 Feb 2019

Evaluation of Synergistic Effect of Green Tea and Horse Gram Powder Extract on the Treatment of Obesity Induced Rats

Dhanalaxmi Mohan Radj1*, K. Bhaskar Reddy2

1. Faculty of Science, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India

2. Sri Venkateswara College of Pharmacy, R.V.S Nagar, Tirupati Road, Chitoor-517127, Andhra Pradesh, India


The present study aimed that evaluation of synergistic effect of green tea and horse gram powder extract on the treatment of obesity induced rats. Extraction of leaf of the Camellia sinensis and legume of Macrotyloma uniflorum with methanolic by Maceruation method. Individually and combined both plants extracted poly herbal extraction and screened for phytochemical study performed Preliminary Phytochemical analysis of crude extracts for individual palnts and poly herbal extraction and evaluated leaf of the Camellia sinensis and legume of Macrotyloma uniflorum and poly herbal extraction for Anti-Hyperlidemic activty activity by Triton X 100 Induced Hyperlipidemia model, High Fat Diet (FD) induced hyperlipidemic model, Estimation of Serum total cholesterol (TC) CHOD- PAP, Estimation of serum triglycerides, Estimation of HDL-cholesterol, Estimation of LDL cholesterol, Phytochemical investigation reveals the presence of alkaloids, flavanoids, saponins, tannins, steroids, triterpinoids, carbohydrates and glycosides in poly herbal methanolic extraction and individual plant extraction, In acute toxicity studies no mortality was observed with either of the extracts even at the dose level of 2000 mg/kg body weight In the present study, the methanol extracts of three plants reduced the cholesterol and triglycerides in a manner similar to the reduction facilitated by atorvastatin. The hypolipidemic activities of atorvastatin and the methanol extract of individual and polyherbal extraction were evident in both synthesis and excretory phases of triton-induced hyperlipidemia in rats.

Keywords: Macrotyloma uniflorum, Camellia sinensis, hyperlipidemia

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