DOI: 10.21276/ajptr
Wed, 27 Mar 2019

Formulation and Evaluation of Mucoadhesive Microspheres Containing Cimetidine

SK. Arifa Begum1,2*, D. Basava Raju3, T. Rama Mohan Reddy4, D.V.R.N Bhikshapathi4

1.Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India

2.Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500072, Telangana,India.

3.Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, India.

4.CMR College of Pharmacy, Kandlakoya (V), Medchal Road, Hyderabad-501401, T.S, India.


In the present research work mucoadhesive microspheres of Cimetidine were prepared using Ionotropic gelation technique. All the microspheres were characterized for particle size, scanning electron microscopy, FT-IR study, DSC, percentage yield, drug entrapment, stability studies and for in vitro release kinetics and found to be within the limits. Among all the formulations M12 was selected as optimized formulation based on the physicochemical and release studies. In vitro drug release study of optimized formulation M12 showed 99.12% after 12 h in a controlled manner, which is essential for anti ulcer therapy. The innovator Cimetine conventional tablet showed the drug release of 96.15% within 1 h. The drug release of Cimetidine optimized formulation M12 followed zero order and Higuchi kinetics indicating diffusion controlled drug release.

Keywords: Cimetidine, mucoadhesion, chitosan, gum kondagogu, xanthan gum.

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