Wed, 22 Nov 2017

Anti-ulcer activity in Trichosanthes Dioica (Roxb.): A Histopathology Report Analysis

Devansh Mehta1*, Anuj Kumar Sharma2

1: Kharvel Subharti College of Pharmacy, Subharti University, Meerut, U.P., India. Pin code: 250110.

2: Translam Institute of Pharmaceutical Education and Research, Meerut, UP. Pincode: 250001


ABSTRACT

Ulcer is lesion on skin or internal linings of organs or Gastro-intestinal tract, which leads to degradation of cells in the area of occurrence which may be followed by bleeding or cancer at later stages. Peptic Ulcer Disease known as Ulcus pepticum have mucosal erosions equal to or greater than 0.5 cm of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. The present study was to evaluate Anti-ulcer activity in Trichosanthes dioica (Roxb.) via experimental ulcer models in animals through Histopathology study of Rat’s stomach. The leaves of Trichosanthes dioica (Roxb.) were collected from farms in and around Hastinapur district. Around two kilograms of the leaves of plant shrub were collected and were kept in shade for the purpose of drying the leaves completely. Sprague-Dawley rats (150 – 200 g) were procured from the animal house of Subharti University (n=90). The three animal models were used for the present study, mainly, Pylorus ligation, Ethanol Induced and Indomethacin (NSAID’s) ulcer models. Five groups of Animals were made, with n=6 for each group. The histopathology study of rat’s stomach was carried out for each ulcer model, and during the examination of rat’s stomach, it was clearly shown, that Trichosanthes dioica has potent Anti-ulcer activity. The Research thus primarily focuses using the plant for further study and to bring an effective and efficient ulcer healing drug in the market.

Keywords: Trichosanthes dioica (Roxb.), Methanolic extract of Trichosanthes dioica (MeTD), Anti-ulcer activity, Histopathology study


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