Wed, 22 Nov 2017

Assessment of the Stability of Paracetamol Pediatric Oral Suspension through Simulate in-Home and in-Use Storage Conditions

Dhia Elhag1*, Laila Fathi1

1.Faculty of Pharmacy, University of Medical Sciences and Technology, Khartoum, Sudan.


ABSTRACT

This study investigates the stability of paracetamol pediatric oral suspension (120mg/5ml) in simulated in-home storage conditions at temperature ranging from (2-8C0) representing refrigerator condition. Samples from suspension were assayed and tested for related substance (degradants) using B.P pharmacopeia HPLC method. The study was performed in day zero, seven, fourteen, thirty and forty five.  The instrument employs column ® C8, 100 x 4.6 mm, 3.5 μm particle size. The mobile phase consisted of methanol, tetrabutylammonium hydroxide (40 %) and sodium orthophosphate buffer. The results showed that the drug assay content remains within the limits up to day fourteen. Furthermore, the half live was found to be 36.8 days.

Keywords: Paracetamol, 4-amino phenol, degradation, HPLC


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