Wed, 22 Nov 2017

Formulation and Evaluation of Candesartan Cilexetil Matrix Tablets

Sindhu Renduchintala1*, Subhash1, Sandeep Urandur2, Sonam Singh3

1. Vivekanada College of Pharmacy.Bangalore

2. Research Scholar, CDRI Lucknow.

3. XL Healthcare Bangalore.


ABSTRACT

Candesartan cilexetil is an antihypertensive drug effective for the treatment of hypertension and heart failure. The main goal is to formulate and evaluate the sustained release matrix tablets of candesartan cilexetil using different polymers like hydrophilic and hydrophobic. Different formulations were prepared by direct compression method using various release retarding polymers like carbopol 934P, HPMC K15M, sod.CMC. Water soluble surfactant SLS was employed for enhancing the solubility of candesartan cilexetil. Drug-excipients compatibility was carried out by FTIR. Different formulations were evaluated for hardness, thickness, friability, drug content and in vitro drug release. The results were found to be satisfactory in terms of physico-chemical parameters. The F10 formulation was found to display highest drug release of drug. Mathematical analysis of the release kinetics was carried out to determine the mechanism of drug release. In vitro release data was fitted into various models to ascertain the kinetic of drug release.

Keywords: Sustained release matrix tablets, HPMCK 15M, carbopol 934P, sodium CMC, SLS, Direct compression, Candesartan cilexetil.


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