DOI: 10.21276/ajptr
Wed, 27 Mar 2019

Development & Evaluation of Mucoadhesive Microspheres Containing Gatifloxacin

K. Nagasree1,2*, G.V. Chowdary3, C.B. Mahendra kumar1

1. St.mary’s College of Pharmacy, Secunderabad, Telangana state, India.

2.Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500072, Telangana,India.

3.Harizon College of Pharmacy, Keesara, RR Dist, Telangana state, India.


Present study aims to prepare and evaluate mucoadhesive microspheres by ionotropic gelation method. Among all the formulations M10 was selected as optimized formulation for mucoadhesive microspheres based on the evaluation parameters and drug release studies. In vitro release study of formulation M10 showed 97.11% 12 h in a controlled manner, which is essential for disease like peptic ulcer. The release order kinetics for M10 was best fit with the highest correlation coefficient was observed in Higuchi model, indicating diffusion controlled principle. The innovator Abygate conventional tablet shows the drug release of 97.23% within 1 h. FT-IR and DSC analyses confirmed the absence of drug-polymer interaction. The results obtained from evaluation and performance study of Gatifloxacin mucoadhesive microspheres that system may be useful to achieve a controlled drug release profile suitable for peroral administration and may help to reduce the dose of drug, dosing frequency and improve patient compliance when compared with marketed product.

Keywords: Gatifloxacin, Mucoadhesiveness, Gum Olibanum, Chitosan, Microspheres.

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