Tue, 21 Nov 2017

Buccal Mucoadhesive Drug Delivery Systems

Amit Singh*1, PranshuTangri1, Lakshmayya

1.GRD(PG)IMT, NDDS Laboratory, Dept. of Pharmacy 214, Rajpur road, Dehradun-248001, Uttarakhand


ABSTRACT

Buccal drug delivery is the most innovative delivery system which releases the drug to buccal mucosa by avoiding first-pass metabolism in the liver and pre-systemic elimination in the gastrointestinal tract. Buccal route is an attractive route of administration for systemic drug delivery. Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, The mucosa of the buccal cavity is the most easily accessible transmuocosal site. Buccal transmucosal delivery helps to bypass first- pass metabolism by allowing direct access to the systemic circulation through the internal jugular vein.

Keywords: First-pass metabolism, Buccal route


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