Tue, 21 Nov 2017

The Effects of Aqueous Extract of Ginger (Zingiber Officinale) On Blood Glucose And Lipid Profile In Cholesterol-Fed Male Diabetic Albino Wistar Rats

Maduka Stephen Ozoemena1, Ugwu Chidiebere Emmanuel2*,Okonkwo Chukwudi Onyeka1, Dimkpa Uchechukwu1, Ezeh Stanley C1.

1.Department of Human Physiology, Faculty of Basic Medical Sciences Nnamdi Azikiwe University, Nnewi Campus.

2. 2Department of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus.


ABSTRACT

Diabetic mellitus goes with metabolic disorders involving hyperglycaemia and lipid disorders. The study investigated the activity of aqueous ginger extract on the glucose level and lipid profile of cholesterol-fed diabetic rats.  The rats were randomly distributed into four groups of 5 rats per group. Group A (control) were placed on normal rat feed. Diabetes was induced in groups B, C, and D by intraperitoneal administration of one dose of alloxan monohydrate (150mg/kg/bwt) and fed diet mixed with 1% cholesterol. The rats in groups C and D were orally administered with 250 and 500mg/kg/bwt of ginger extract respectively for 14 days. Biochemical parameters were analysed by standard methods. A significant decrease (P<0.05) in the blood glucose concentration in the ginger administered groups (C and D) was observed compared to diabetic cholesterol-fed rats (group B). After 14 days of aqueous ginger extract administration (250 and 500mg/kg/bwt), the serum total cholesterol level reduced in the test groups (C and D) relative to the test control group (group B) (P>0.05). There was a statistical increase in the serum triacylglycerol level in group B compared to group A (P<0.05) but the extract administration at 500mg/kg/bwt significantly led to a reduction of triacylglycerol compared to group B (P<0.05). It can be concluded that the extract possess hypoglycaemic and hypolipidaemic properties and confirms its use in the traditional medicine. This result should be taken with caution as the extract did not restore the serum levels of these parameters to the same levels as the non-diabetic control groups.

Key words: alloxan, Ginger, glucose, lipid profile.


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