DOI: 10.21276/ajptr
Fri, 24 May 2019

The effects of chronic administration of Aloe vera gel on some haematological, hemostasis and electrolytes indicies on wistar albino rats.

Maduka Stephen Ozoemena1, Ugwu Chidiebere Emmanuel2*, Iloka Emeka Paul1.

1. Department of Human Physiology, Faculty of Basic Medical Sciences Nnamdi Azikiwe University, Nnewi Campus.

2. Department of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus


There are folkloric claims that Aloe vera has many pharmacological properties which have not been conclusively investigated. The aim of the study is to investigate the protective/toxic effects of chronic administration of Aloe vera gel extract on the haemostasis, haematology and renal handling of electrolytes, urea and creatinine in Wistar rats. The experimental animals were grouped into four: group 1(control) received vehicle and the test groups (2,3,4) received different doses of the extract (200, 300, and 500mg bwt/day ) respectively for 21 days. The bleeding time significantly decreased as the concentration of the extract increased while the clotting time increased relative to the control (P<0.05). The packed cell volume was only significantly decreased in group four (P<0.05) while the control group had a higher white blood cell count compared to the test groups (P>0.05). The serum electrolytes, urea and creatinine were not altered significantly (P>0.05). From the results of this study, it can be concluded that the chronic administration of Aloe vera gel did not disrupt the renal function of the wistar rats. 

Keywords: Aloe vera, haematology, haemostasis, electrolyte.

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